منابع مشابه
Homocysteine and cardiovascular disease.
An elevated level of total homocysteine (tHcy) in blood, denoted hyperhomocysteinemia, is emerging as a prevalent and strong risk factor for atherosclerotic vascular disease in the coronary, cerebral, and peripheral vessels, and for arterial and venous thromboembolism. The basis for these conclusions is data from about 80 clinical and epidemiological studies including more than 10,000 patients....
متن کاملHomocysteine and vascular disease.
For more than 20 years, moderately raised concentrations of total homocysteine (tHcy) have been associated with an increased risk of atherothrombotic vascular events but only recently has evidence mounted to suggest that the association may be causal. The association is independent of other factors, it is fairly consistent across many studies, it is strong and dose-related, and it is biological...
متن کاملHomocysteine and "Buerger's disease".
42 year old woman presented with ischaemic left leg pain. There had been a right above knee amputation two years previously when Buerger's disease was diagnosed. However, on review of the arteriogram there was proximal disease in the superficial femo-ral artery suggesting atherosclerotic disease , and typical arteriographic features of Buerger's disease were absent. She had been a smoker of 30 ...
متن کاملHomocysteine and vascular disease.
In my experience the largest individual group of sufferers from recurrent and especially incessant pericarditis have been those without recurrent effusions who are presumed, though rarely firmly demonstrated (as here), to have an immunopathy, and especially those who are ‘steroid hooked’. Indeed, there is some evidence that corticosteroid treatment has been necessary to initiate the cycle of re...
متن کاملHomocysteine and thrombotic disease.
amino acid whose metabolism is at the intersection of The more severe cases of hyperhomocysteinemia are two metabolic pathways: remethylation and transsulfuration caused by homozygous defects in genes encoding for en(Fig 1). In remethylation, homocysteine acquires a methyl zymes of homocysteine metabolism. In such cases, a defect group from N-5-methyltetrahydrofolate (MTHF) or from bein an enzy...
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ژورنال
عنوان ژورنال: Archives of Neurology
سال: 2000
ISSN: 0003-9942
DOI: 10.1001/archneur.57.10.1422